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USP3 activates Neuroblastoma. 4 / 4
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"Nagy et al. reported that USP3 promotes neuroblastoma cell viability, proliferation, and xenograft tumor growth by cleaving K48‐ and K63‐linked ubiquitin chains of MYCN (Figure 2C, right)."
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"In neuroblastoma patients, the m C reader ALYREF forms a nuclear coactivator complex with MYCN to stimulate USP3 transcription, which promotes the tumorigenesis of neuroblastoma (89)."
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"Furthermore, the activation of USP3 induces neuroblastoma [35]."
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"ALYREF and MYCN form a transcriptional activator complex, which upregulates USP3 expression, promoting the growth and tumorigenicity of MYCN-amplified neuroblastoma cells [24]."
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