IndraLab

Statements

USP22 activates CCNB1. 8 / 10
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"Phosphorylation of USP22 at T147 and S237 by CDK1 increases the deubiquitination status of cyclin B1 in a cell cycle dependent manner."
34660907
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"Our discovery here, that both USP22 and CCNB1 proteins are elevated and positively associated in human colon cancers, indicates that USP22 mediated CCNB1 stabilization is one possible molecular mechanism underlying its proto-oncogenicity."
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"In addition, phosphorylation of Thr147 and Ser237 of USP22 by CDK1 enhances the deubiquitination activity of USP22 on cyclin B1."
33989708
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"USP22 mediated CCNB1 stabilization is regulated by both CDK1 and the APC/C E3 ubiquitin ligase complex."
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"In addition, Usp22 promotes CRC by stabilizing cyclin B1."
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"Moreover, the proteasome inhibitor MG132 protected CCNB1 from degradation in usp22 knockdown cells (XREF_FIG), implying that USP22 mediates CCNB1 stabilization through regulating the proteasomal pathway."
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"Given that degradation of CCNB1 is required for cells to exit M phase and enter anaphase [XREF_BIBR, XREF_BIBR], we proposed that USP22 degradation, which presumably allows CCNB1 degradation during late M phase, is necessary for cell cycle regulation."
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"Therefore, APC and CDC20 E3 ligase complex promotes USP22 protein degradation, presumably allowing CCNB1 degradation for cells to exit M phase."
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