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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Wnt decreases the amount of SCN5A. 3 / 3

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"Ventricular Notch activation upregulates Scn5a expression, while ectopic Wnt activation downregulates Scn5a expression, consistent with programming to an AV junction like phenotype."

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"Chromatin immunoprecipitation showed that Wnt signalling inhibits Scn5a expression through downstream mediator (TCF4) binding to both Tbx3 and Scn5a promoters."

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"In addition, activation of canonical Wnt signaling has been shown to decrease SCN5A mRNA levels, Na 1.5 protein and Na current density in rat ventricular myocytes."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

Wnt decreases the amount of SCN5A. 3 / 3

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