IndraLab

Statements

USP22 binds end3. 16 / 16
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"SIRT1, a class III histone deacetylase, serves as an acetylation mediator within the USP22 and SAGA coactivator complex [ xref , xref ]."
38702734
sparser
"USP22 forms part of the SAGA complex and requires the participation of cofactors like ATXN7L3 and ENY2 to deubiquitinate H2B, while USP27X functions independently of SAGA but also needs ATXN7L3 and ENY2 to act on H2B [ xref ]."
30613357
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"GCN5 has been shown to support the association of USP22 with the SAGA complex."
28412741
reach
"Although this shows USP22 can bind both PALB2 and SAGA it does not delineate whether these are two separate populations or whether USP22 can interact with all of these components including PALB2 at the same time."
31685642
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"Like in Drosophila , USP22 associates with human SAGA, and is recruited to specific genes by activators such as the MYC oncoprotein for transcription [ xref ]."
20800707
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"On the contrary, as a part of the SAGA complex, USP22, by deubiqitinating TRF1, restores its protein level and thereby maintains telomeric length."
34660907
sparser
"We successfully identified many protein complexes known to associate with glucose starvation and revealed connections with many other complexes, of which identified modulated Emerin complex 1 and USP22-SAGA complexes are experimentally validated by co-IP."
38001062
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"SAGA and USP22 inducibly bind to the promoter region of ER stress response genes."
34155658
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"GCN5 was found to be required for USP22 to properly associate with the SAGA complex and to be able to deubiquitinate TRF1 and prevent its turnover ( xref )."
28588610
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"One is Emerin complex 1 which function to organize the nuclear membrane during cytokinesis xref , and the other is USP22-SAGA complex which function is a regulatory center for signaling, chromatin modification, DNA damage repair, and gene control xref ."
38001062
sparser
"Slim-TPCA analysis revealed increased association between subunits for both Emerin complex 1 and USP22-SAGA complex during glucose deprivation which was recapitulated in our Co-IP experiments (Fig.  xref )."
38001062
sparser
"GCN5 is required for the association of SAGA with USP22, which is the component of its deubiquitination module, and the subsequent USP22-mediated deubiquitination of TRF1, which inhibits TRF1 degradation by proteasomes, thereby preventing signalling associated with telomere DNA damage and protecting telomeres from fusions."
28412741
reach
"This raises the hypothesis that once USP22 associates with SAGA and GCN5, it may oppose telomere recombination in APBs by promoting the binding of POT1 to telomeres via TRF1, thereby inhibiting ATR activation."
28412741
sparser
"SIRT1 is a mediator of acetylation of the USP22 and SAGA coactivator complex."
35935969
reach
"One is Emerin complex 1 which function to organize the nuclear membrane during cytokinesis , and the other is USP22-SAGA complex which function is a regulatory center for signaling, chromatin modification, DNA damage repair, and gene control ."
38001062
reach
"Slim-TPCA analysis revealed increased association between subunits for both Emerin complex 1 and USP22-SAGA complex during glucose deprivation which was recapitulated in our Co-IP experiments (Fig. 6d)."
38001062