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Minocycline inhibits CASP1. 31 / 37
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"Minocycline reduces traumatic brain injury mediated caspase-1 activation, tissue damage, and neurological dysfunction."
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"Recently, several reports have indicated that minocycline, a second-generation semi-synthetic tetracycline with a broad-spectrum antimicrobial activity ( Amin et al., 1996; Golub et al., 1998 ), effec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, minocycline inhibits certain matrix metalloproteases ( Power et al., 2003 ) as well as caspase-1 and caspase-3 ( Chen et al., 2000; Zhu et al., 2002 ) by reducing their mRNA expression."
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"Moreover, minocycline inhibits certain matrix metalloproteases ( Power et al., 2003 ) as well as caspase-1 and caspase-3 ( Chen et al., 2000; Zhu et al., 2002 ) by reducing their mRNA expression."
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"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [ xref ]."
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"Minocycline inhibits caspase-1 and caspase-3, which are involved in the generation of interleukin-1 and the induction of apoptosis, respectively."
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"Minocycline was also able to suppress the activation of caspase-1 XREF_BIBR."
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"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [XREF_BIBR]."
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"Minocycline reduces traumatic brain injury mediated caspase-1 activation, tissue damage, and neurological dysfunction."
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"Minocycline also inhibited the up-regulation and activation of iNOS, cyclooxygenase-2, caspase-1 and caspase-3 and p38-mitogen-activated protein kinase ( Chen et al., 2000; Popovic et al., 2002; Sanch[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Retrospective multicentre cohort studies have shown that minocycline inhibits caspase-1 to reduce the incidence of acute renal failure ( xref )."
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"Minocycline can inhibit caspase-1 signalling pathways, attenuating the subsequent maturation and secretion of IL-1β (Wong et al., 2016)."
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"For example, treatment of mice that overexpress a mutant huntingtin transgene with minocycline, which inhibits both caspases-1 and -3, delays the death of the animals [20] ."
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"Accordingly, systemic administration of minocycline, a second-generation tetracycline, inhibited the up-regulation of caspase 1 and inducible nitric oxide synthetase (iNOS) in the brain of R6/2 mice, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The first example of minocycline-induced neuroprotection was shown in an animal model of ischemic stroke [29] , where minocycline reduced caspase-1 and inducible nitric oxide synthase (iNOS) mRNA."
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"Isatin sulfonamides have been described as potent and selective non peptidic caspase-3 and -7 inhibitors [58], but no development has as yet been reported.The second generation tetracycline antibiotic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, it was reported that mice lacking caspase 1 or treatment of wild-type mice with a semisynthetic antibiotic minocycline, which potentially functions to inhibit caspase 1 and modulates the gut microbiota, are protected from developing depressive-like and anxiety-like behaviours, even when experiencing chronic stress ."
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"Minocycline, a tetracycline-derivative antibiotic, which can bind to the 30S ribosome in prokaryotes and inhibit translation, has been also shown to inhibit caspase-1 activation in R6/2 mice, while tetracycline has no effect."
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"Retrospective multicentre cohort studies have shown that minocycline inhibits caspase-1 to reduce the incidence of acute renal failure (232)."
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"At 2 months of diabetes, minocycline inhibited hyperglycemia induced caspase-1 activity and IL-1beta production in the retina."
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"Minocycline, a tetracycline antibiotic with high CNS penetration when taken orally, inhibits caspase-1 and caspase-3 enzymes and decreases activity of inducible nitric oxide synthase [53]."
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"Minocycline inhibits casp-1 expression during stroke ( Yrjanheikki and others 1999 ) and has the additional benefit of inducing the expression of anti-apoptotic Bcl-2 ( Wang and others 2004 ) ."
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"Our findings are in line with the previous report by Chen et al., who demonstrated that minocycline could inhibit caspase-3 and caspase-1 and postpone mortality in a transgenic mouse model of Huntington disease (Chen et al., 2000[4])."
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"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."
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"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."
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"Antibiotics such as minocycline or other agents that block caspase-1/IL-1β can be used as non-invasive treatments [17]."
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"We report that minocycline delays disease progression, inhibits caspase-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity."
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"However, the exact mechanism by which minocycline inhibits caspase 1 is still to be elucidated and it is beyond the scope of this review [ xref ]."
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"These results demonstrated that CGRP and minocycline could inhibit microglial activation and NLRP3/caspase-1 pathway in the spinal cord, and relieved hyperalgesia in DLBP rats.4 Discussion."
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"The same group found that minocycline inhibits caspase-1, caspase-3, and iNOS activities in HD animals and observed a reduction in both disease progression and mortality of R6/2 animals [XREF_BIBR]."
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"Yrjanheikki et al. [162] reported that either doxycycline or minocycline could reduce mRNA induction of IL-1beta converting enzyme and protect against neuronal death after ischaemic stroke."
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