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Minocycline inhibits CASP1. 20 / 20
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"Minocycline inhibits casp-1 expression during stroke ( Yrjanheikki and others 1999 ) and has the additional benefit of inducing the expression of anti-apoptotic Bcl-2 ( Wang and others 2004 ) ."
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"However, the exact mechanism by which minocycline inhibits caspase 1 is still to be elucidated and it is beyond the scope of this review [ xref ]."
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"Minocycline reduces traumatic brain injury mediated caspase-1 activation, tissue damage, and neurological dysfunction."
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"For example, treatment of mice that overexpress a mutant huntingtin transgene with minocycline, which inhibits both caspases-1 and -3, delays the death of the animals [20] ."
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"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."
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No evidence text available
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"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [ xref ]."
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"Caspase 1 inhibition by minocycline slows degeneration and disease progression in mouse models of HD [XREF_BIBR]."
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"Furthermore, it was reported that mice lacking caspase 1 or treatment of wild-type mice with a semisynthetic antibiotic minocycline, which potentially functions to inhibit caspase 1 and modulates the gut microbiota, are protected from developing depressive-like and anxiety-like behaviours, even when experiencing chronic stress ."
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"The same group found that minocycline inhibits caspase-1, caspase-3, and iNOS activities in HD animals and observed a reduction in both disease progression and mortality of R6/2 animals [XREF_BIBR]."
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"Furthermore, it was reported that mice lacking caspase 1 or treatment of wild-type mice with a semisynthetic antibiotic minocycline, which potentially functions to inhibit caspase 1 and modulates the gut microbiota, are protected from developing depressive-like and anxiety-like behaviours, even when experiencing chronic stress253."
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"At 2 months of diabetes, minocycline inhibited hyperglycemia induced caspase-1 activity and IL-1beta production in the retina."
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"After ischemia, minocycline inhibits caspase-1 and inducible nitric oxide synthetase upregulation, and reduces infarction."
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"Minocycline, a tetracycline-derivative antibiotic, which can bind to the 30S ribosome in prokaryotes and inhibit translation, has been also shown to inhibit caspase-1 activation in R6/2 mice, while tetracycline has no effect."
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"Minocycline was also able to suppress the activation of caspase-1 XREF_BIBR."
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"Minocycline, a tetracycline antibiotic with high CNS penetration when taken orally, inhibits caspase-1 and caspase-3 enzymes and decreases activity of inducible nitric oxide synthase [53]."
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"We report that minocycline delays disease progression, inhibits caspase-1 and caspase-3 mRNA upregulation, and decreases inducible nitric oxide synthetase activity."
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"Isatin sulfonamides have been described as potent and selective non peptidic caspase-3 and -7 inhibitors [58], but no development has as yet been reported.The second generation tetracycline antibiotic[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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No evidence text available
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"Minocycline inhibits caspase-1 and caspase-3, which are involved in the generation of interleukin-1 and the induction of apoptosis, respectively."
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