IndraLab

Statements

HCN4 activates BMP4. 2 / 2
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"Both overexpressing HCN4 and injection of dominant negative HCN4 mRNA disrupt the localization of key morphogenetic patterning genes, Xnr-1, Lefty, Pitx2, and BMP-4, resulting in hearts with incorrect positional orientation and morphology."
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"The immunofluorescence assay revealed that the expression of SHOX2 and HCN4 increased in the BMP4 + CHIR group compared to that in the other groups."
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