IndraLab

Statements

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"HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K and AKT pathway."
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"For example, inhibition of the potassium channels, KCNK9 [XREF_BIBR], Kv10.1 [XREF_BIBR], hEag1 [XREF_BIBR], and HERG1 [XREF_BIBR] inhibited tumor metastasis, as did inhibition of the sodium channels, Na (v1.4) [XREF_BIBR] and Na (v) 1.5 [XREF_BIBR] and the sodium proton exchanger, NHE1 [XREF_BIBR, XREF_BIBR]."
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"Interestingly, however, it also has been demonstrated that blockade (rather than activation) of Kv11.1 in colon cancer cells can inhibit metastasis [44]."
| PMC
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"HERG1 knockdown reduced tumor growth and metastasis in athymic mice."
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"In addition, the activation of Kv11.1 inhibited EMT and blocked the cancer metastasis by β-catenin in breast cancer ."
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"Functionally, hERG1 may contribute to survival, proliferation, and metastasis of tumor cells."
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"Blockade of the hERG potassium channel proteins by specific agents can inhibit the proliferation and metastasis of tumor cells and the corresponding [XREF_BIBR, XREF_BIBR], increasing the sensitivity of tumor cells to chemotherapeutic drugs."
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"Given that overexpression of hERG1 promotes proliferation, migration and metastasis in ovarian cancer [49,50] , it was suggested that loss of expression of hERG1 by methylation could be a good prognos[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG1 displays a similar role in cancer lines, where hERG1 promotes proliferation and metastasis (51, 52)."
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"Wang et al. showed that human ether a-go-go-related gene 1 (HERG1) promoted ESCC cell proliferation and metastasis through activating the PI3K/Akt signaling pathway (24)."
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