IndraLab

Statements

SGK1 activates KCNQ1. 7 / 10
| 7
reach
"SGK1 stimulates KCNQ1, which is required for luminal K+ recycling and thus for gastric acid secretion."
19255508
reach
"In conclusion, pioglitazone increases gastric acid secretion, an effect at least partially due to stimulation of SGK1 expression and SGK1 dependent upregulation of KCNQ1."
19710534
reach
"One of the genes regulated by cortisol is the serum- and glucocorticoid inducible kinase 1 (SGK1) a stimulator of the slow outward potassium channel KCNQ1 and KCNE1-one of the major mediators of cardiac repolarization."
19372749
reach
"They enhance transcription of the serum and glucocorticoid inducible kinase SGK1, which could in turn enhance gastric acid secretion by stimulating KCNQ1 K+ channels."
19710534
reach
"KCNQ1 and H +/K +-ATPase protein abundance in the parietal cell membrane was enhanced by pioglitazone treatment in sgk1 +/+ but not in sgk1-/- mice."
19710534
reach
"Moreover, SGK1 could stimulate proximal renal tubular glucose transport by stimulation of the K + channels KCNQ1 and KCNE1, which establish the electrical driving force for electrogenic glucose transport."
19764891
reach
"The effect of APC requires H +/K+ ATPase activity and is at least partially due to SGK1 dependent upregulation of KCNQ1."
19255508