IndraLab

Statements

Hydroxychloroquine increases the amount of NOS2. 2 / 2
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"Hydroxychloroquine polarized macrophages from the M2- to the M1-like state, which was characterized by spindle-shape, increased pseudopods, and upregulated iNOS expression in melanoma mice; moreover, it induced macrophages to release IFN-β, thereby inducing T cell-mediated cytotoxicity and notably increasing the ratio of M1 macrophages following combination therapy with PD-1 antibody (124)."
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"However, HCQ did not reduce the high expression of iNOS, and 20 μM HCQ markedly increased iNOS expression (p < 0.001, Fig. 6d )."
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