IndraLab

Statements

USP19 inhibits Ubiquitin. 2 / 2
| 2
reach
"RNF216 interacts with and ubiquitinates Beclin 1 at lysine 48, thereby contributing to Beclin 1 degradation, while SLC9A3R1 and USP19 blocks ubiquitin dependent Beclin 1 degradation by interacting with Beclin 1 and removing the K11 linked ubiquitin respectively."
33425768
reach
"Taken together, USP19 suppresses pTh17 differentiation and pathogenic potential through the removal of K63-linked ubiquitin chain from lysine 313 of RORγt, which is required for recruiting coactivator SRC3 and essential for the expression of proinflammatory effectors (Fig. 6E)."
34135062