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UBQLN2 activates ATXN3. 2 / 2

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"Remarkably, instead of reducing the accumulation of nuclear mutant ATXN3, UBQLN2 induced an accumulation of cytoplasmic ATXN3 aggregates in neurons of SCA3 mice."

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"These findings suggest that ATXN3 may not be a substrate for UBQLN2 mediated clearance.In HD, SCA3, and other polyQ disorders, impairment of protein homeostasis and sequestration of clearance related [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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IndraLab

Statements

UBQLN2 activates ATXN3. 2 / 2

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