IndraLab

Statements

OTUB2 binds GLI2. 12 / 12
3 | 1 8
biogrid
No evidence text available
30241937
biogrid
No evidence text available
30241937
biogrid
No evidence text available
30241937
sparser
"We provided evidence that OTUB2 binds to and deubiquitinates Gli2, playing a critical role in regulating the Hh signaling pathway."
30241937
sparser
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"Furthermore, we confirmed that OTUB2 could bind to Gli2, which indicated that Gli2 were substrates for OTUB2."
30241937
sparser
"To identify the interactions between endogenous Gli2 and OTUB2, HEK293A cells were transfected with Flag-tagged OTUB2 construct or vector control, and the cell lysate was subjected to immunoprecipitat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30241937
sparser
"To identify the interactions between endogenous OTUB2 and Gli2, HEK293A cells were transfected with Flag-tagged Gli2, then the cell lysate was subjected to IP using anti-Flag magnetic beads (M8823, Si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30241937
reach
"The authors found that OTUB2 formed a complex with Gli2 and promoted Gli2 deubiquitination both in vitro and in vivo."
| PMC
sparser
"Meanwhile, the interaction between OTUB2 and Gli2 was determined by immunoprecipitation ( xref )."
35309903
sparser
"To detect whether OTUB2 interacted with endogenous Gli2 protein, we transfected Flag-tagged OTUB2 into HEK293A cells."
30241937
sparser
"To identify the interactions between endogenous OTUB2 and Gli2, we transfected Flag-Gli2 into 293A cells."
30241937