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Chelator inhibits PSMD14. 2 / 2

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"Ovaa et al. reported a mono-Ub probe (Fig. 13e) with a zinc chelator 8-mercaptoquinoline (8-MQ) linked to the C terminus of Ub.129 Inhibition assays showed that the probe can inhibit Rpn11/Rpn8 with an IC50 value about 2 μM."

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"Thiolutin ( 42 ), a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces, was reported to function as a zinc chelator that inhibits RPN11 and other JAMM metalloproteases [ xref ]."

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Chelator inhibits PSMD14. 2 / 2

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