IndraLab

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OTUB2 activates RIPK3. 6 / 6
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"Moreover, OTUB2 increased RIPK3 protein abundance by inhibiting the proteasomal degradation of RIPK3."
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"Collectively, these findings show that OTUB2 enhances ischemia-induced neuronal necroptosis by regulating RIPK3 through its DUB activity."
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"Moreover, the protein abundance of RIPK3 was significantly reduced in OTUB2-deficient brains (Fig. 3A,F), suggesting that OTUB2 may modulate the necroptotic signaling by targeting RIPK3."
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"In line with these in vitro results, in the mouse brain, OTUB2 deficiency reduced RIPK3 only at protein levels but not mRNA levels, whereas both protein and mRNA levels of RIPK1 were not altered by OTUB2 deletion (Appendix Fig. S6E–I)."
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"Functionally, deletion of OTUB2 accelerated the degradation of RIPK3 while OTUB2 overexpression delayed RIPK3 degradation (Fig. 4J,K; Appendix Fig. S8)."
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"Given that RIPK3 critically regulates necroptosis and that OTUB2 increases RIPK3 abundance and activity, we then assessed whether OTUB2 enhanced neuronal necroptosis via regulating RIPK3."
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