IndraLab

Statements

Arg-Val inhibits IFNB1. 7 / 7
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"Ex vivo studies in airway epithelial cells found that RV induced IFN-beta and IFN-lambda responses were impaired in subjects with asthma, leading to increased viral replication and shedding and exaggerated secondary responses [XREF_BIBR, XREF_BIBR]."
27871304
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"Similarly, asthma was associated with lower fold increases in RV induced IFNB1 mRNA (p = 0.01) and IL28 mRNA (p = 0.009)."
24219422
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"Ex vivo studies in airway epithelial cells found that RV-induced IFN-β and IFN-λ responses were impaired in subjects with asthma, leading to increased viral replication and shedding and exaggerated secondary responses [85, 86]."
27871304
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"Cultured primary BECs from adults with allergic asthma exhibit lower levels of RV induced IFNbeta (a type I IFN), lower levels of virus induced apoptosis and higher RV loads than cells from control adults 127."
22669219
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"Only a previous infection with RV was able to reduce by 60% the IFN-β mRNA levels produced after polyI:C transfection, although differences were not statistically significant (Fig 6A)."
25837699
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"Such reduced infectivity of basolaterally administered RV correlated with marked attenuation of IRF7, STAT1, and PKR activation and induced secretion of IFN-beta and IL-8 (XREF_FIG)."
20664578
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"The deficient IFN-beta observed was not related to GC use, as GC treated and GC naive asthmatic individuals exhibited similar levels of reduced RV induced IFN-beta."
23212197