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KCNB1 inhibits INS. 3 / 3
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"Although we had already found that KCNB1 rs1051295 genotype TT was associated with T2D and decreased insulin sensitivity in our previous study, no association was observed for rs1051295 and insulin resistance in either dominant model (P = 0.72, OR = 1.07 (0.75,1.51)) or recessive model (P = 0.24, OR = 0.75 (0.47,1.20)) by univariate or multivariate analysis in this study."
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"In our previous study, we had assessed in the Chinese Han population the association of KCNB1 rs1051295 with metabolic traits indicating metabolic syndrome, and showed that KCNB1 rs1051295 genotype TT was associated with increase of waist to hip ratio (WHR), fasting insulin (FINS), triglycerides (TG) and decreased insulin sensitivity at basal condition."
26377690
reach
"For example, glucose induced the de-phosphorylation of Ca 2+ -dependent protein phosphatase calcineurin target site on voltage gated potassium channel Kv2.1 (Kcnb1), which would activate this K + channel and increase outward K + currents thus impaired insulin exocytosis 31."
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