IndraLab

Statements

TLR activates TNFAIP3. 3 / 3
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"Consistent with these observations, treatment of A20 deficient mice with broad-spectrum antibiotics rescues the severe inflammation and lethality, indicating that a dysregulated response to commensal intestinal flora is responsible for the constitutive TLR signaling in Tnfaip3 -/- mice [XREF_BIBR]."
21119682
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"We noted the amounts of pro-IL-1beta expressed in wt and Tnfaip3 -/- cells induced by various TLR ligands correlated poorly with the amounts of secreted mature IL-1beta (XREF_FIG)."
25607459
reach
"To determine whether the secreted IL-1beta was proteolytically mature, we immunoprecipitated (IP 'd) IL-1beta from the supernatants of TLR stimulated Tnfaip3 -/- cells and assessed the molecular weight of the secreted IL-1beta by immunoblotting (IB)."
25607459