IndraLab

Statements

Mitoxantrone inhibits USP11. 9 / 10
| 5 4
reach
"Burkhart et al., using a fluorescent based high-throughput assay, screened more than 2000 FDA approved chemical entities and reported that mitoxantrone inhibits USP11 activity under in-vitro conditions."
31481479
reach
"We first determined whether mitoxantrone inhibits USP11 deubiquitinase activity."
29483509
reach
"Mitoxantrone (MX), an anti-cancer drug, was reported to inhibit USP11."
27448760
sparser
"Interestingly, we found that in Panc1 cells that have previously been shown to have high amounts of USP11 mRNA and to undergo dose-dependent cell death upon treatment with mitoxantrone that inhibits USP11 ( xref ), cell viability is highly affected by FYLIR peptide exposure."
30373771
sparser
"Moreover, inhibition of USP11 by Mitoxantrone (It was original developed as type II DNA topoisomerase inhibitor."
28040451
sparser
"Indeed, depletion of USP11 or inhibition of USP11 by a non-specific inhibitor Mitoxantrone led to significantly sensitization of triple negative breast cancer cells to the chemo-therapeutic agent cisplatin further confirming the therapeutic value of targeting USP11."
28040451
reach
"Moreover, inhibition of USP11 by Mitoxantrone (It was original developed as type II DNA topoisomerase inhibitor."
28040451
sparser
"Our observation that depletion of USP11 or inhibition of USP11 by a non-specific USP11 inhibitor Mitoxantrone significantly sensitized triple negative breast cancer cells to the chemo-drug cisplatin further supports USP11 as a potential target for anti-cancer treatment."
28040451
reach
"Mitoxantrone inhibits USP11 thus offering opportunities for targeting the BRCA1-MYCN interaction [148]."
| PMC