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Mitoxantrone inhibits USP11. 15 / 16
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"Interestingly, we found that in Panc1 cells that have previously been shown to have high amounts of USP11 mRNA and to undergo dose-dependent cell death upon treatment with mitoxantrone that inhibits USP11 ( xref ), cell viability is highly affected by FYLIR peptide exposure."
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"The evidence indicates that targeted inhibition of USP11 by mitoxantrone alleviates the occurrence of aGvHD in mice.To reveal the mechanism of aGvHD induced by USP11, we first examined the hematopoiet[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We first determined whether mitoxantrone inhibits USP11 deubiquitinase activity."
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"Burkhart et al., using a fluorescent based high-throughput assay, screened more than 2000 FDA approved chemical entities and reported that mitoxantrone inhibits USP11 activity under in-vitro conditions."
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"Consistently, we also found that NF- κ B was more restrained in nuclei after USP11 was inhibited by mitoxantrone."
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"Moreover, inhibition of USP11 by Mitoxantrone (It was original developed as type II DNA topoisomerase inhibitor."
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"In addition, research has revealed that mitoxantrone can inhibit USP11 and affect the survival of pancreatic ductal adenocarcinoma cells [ xref ]."
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"Mitoxantrone inhibits USP11 thus offering opportunities for targeting the BRCA1-MYCN interaction [148]."
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"Indeed, depletion of USP11 or inhibition of USP11 by a non-specific inhibitor Mitoxantrone led to significantly sensitization of triple negative breast cancer cells to the chemo-therapeutic agent cisplatin further confirming the therapeutic value of targeting USP11."
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"In addition, research has revealed that mitoxantrone can inhibit USP11 and affect the survival of pancreatic ductal adenocarcinoma cells [48]."
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"In context of deubiquitinating enzymes (DUBs), mitoxantrone was first reported to inhibit USP11 with IC 50 value of ∼3 µM, a close homolog of USP15, and one of the important targets in pancreatic duct[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, inhibition of USP11 by Mitoxantrone (It was original developed as type II DNA topoisomerase inhibitor."
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"The evidence indicates that targeted inhibition of USP11 by mitoxantrone alleviates the occurrence of aGvHD in mice."
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"Our observation that depletion of USP11 or inhibition of USP11 by a non-specific USP11 inhibitor Mitoxantrone significantly sensitized triple negative breast cancer cells to the chemo-drug cisplatin further supports USP11 as a potential target for anti-cancer treatment."
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"Mitoxantrone (MX), an anti-cancer drug, was reported to inhibit USP11."
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