IndraLab

Statements

reach
"Both types take part in Cl - secretion in rat colon : Ca 2+ -dependent rSK4 channels (Warth et al., 1999) and cyclic AMP activated KCNQ1 and KCNE3 channels (Schroeder et al., 2000)."
12799067
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"FFA also inhibited activities of CFTR, a cAMP activated apical Cl - channel, and KCNQ1 and KCNE3, a cAMP activated basolateral K + channel."
28651800
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"In summary, we have shown for the first time that cAMP stimulated KCNQ1 and KCNE3 channels reside in the basolateral membrane of healthy human colonic crypt cells, and that their activity is increased in active UC."
26718405
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"Small conductance basolateral (KCNQ1/KCNE3) K channels are activated by cAMP, while both Ca and cAMP activate basolateral IK channels."
30215859
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"Because XREF_FIG suggests that co-expression of KCNE2 and KCNQ1 should result in functionally responsive channels to cAMP challenges, we next tested whether an external application of a membrane permeable cAMP (cpt-cAMP) enhances KCNE2 and KCNQ1 currents (note that in all experiments Yotiao was also expressed)."
19077539
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"KCNQ1/KCNE2 K+ channels are stimulated by cAMP, and low extracellular pH was found to increase KCNQ1/KCNE2 current (158, 159)."
31670611
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"Elevations in the levels of cAMP, cyclic guanosine monophosphate (cGMP), and Ca 2+ activate apical Cl - channels (CFTR and CaCC) and basolateral K + channels (KCNQ1 and KNE3, KCNN4)."
22850599
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"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
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"KCNQ1 currents were activated by an increase in intracellular cAMP, independent of coexpression with KCNE1 or KCNE3."
11426298
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"We detected endogenously expressed KCNQ1 and KCNE2 proteins, which appeared to be upregulated by TSH or its major downstream effector, cAMP, in FRTL5 cell membrane fractions (XREF_FIG)."
19767733
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"The cAMP activated cystic fibrosis transmembrane conductance regulator (CFTR) and KCNQ1 channels in tracheal epithelium play key roles in luminal and basolateral membranes, respectively."
17567648
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"The gastric KCNQ1 and KCNE channels are activated by cAMP [XREF_BIBR - XREF_BIBR], which thus stimulates gastric acid secretion [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21113728
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"It is known that Cl - secretion induced by quercetin does not require the activation of cyclic AMP activated K + basolateral KCNQ1 and KCNE3 channels (Cermak et al., 2002)."
12799067
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"Mutations at KCNQ1 residue 27 ablated the cAMP induced enhancement of KCNE2 and KCNQ1 currents regardless of substituted amino acid residue (XREF_FIG), suggesting that the cAMP dependent functional regulation is a consequence of PKA mediated phosphorylation at Ser 27 of KCNQ1."
19077539
reach
"Relevant colonic epithelial K+ channels are the intermediate conductance Ca2 +-activated K (Ca) 3.1 (SK4) channel and the cAMP activated K (V) 7.1 (KCNQ1) channel."
17305705