IndraLab

Statements

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"In summary, we have shown for the first time that cAMP stimulated KCNQ1 and KCNE3 channels reside in the basolateral membrane of healthy human colonic crypt cells, and that their activity is increased in active UC."
26718405
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"In addition, fenofibrate inhibits intestinal cAMP-stimulated Cl - secretion by blocking the basolateral KCNQ1/KCNE3 K + channels ( Bajwa et al., 2007 )."
28716724
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"KCNE1 largely enhances the AO state and therefore boosts the cAMP-induced current increase of KCNQ1."
39434867
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"Basolateral UDP activates cAMP-stimulated basolateral KCNQ1/KCNE3 K + channels, which leads to sustained activation of Cl − secretion.As described above, P2YRs play important roles in cardiovascular h[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28648830
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"Relevant colonic epithelial K+ channels are the intermediate conductance Ca2 +-activated K (Ca) 3.1 (SK4) channel and the cAMP activated K (V) 7.1 (KCNQ1) channel."
17305705
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"Our data shows that basolateral KCNQ1 currents are stimulated by the cAMP-dependent CT but insensitive to stimulation by the cGMP-dependent STa secretagogues."
21600231
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"Small conductance basolateral (KCNQ1/KCNE3) K channels are activated by cAMP, while both Ca and cAMP activate basolateral IK channels."
30215859
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"The cAMP-mediated Cl − secretion is activated by secretagogues that increase intracellular cAMP levels which also activate KCNQ1:KCNE3 channels."
22410439
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"Many epithelia express cAMP and/or Ca -stimulated K channels, e.g., cAMP-activated Kv7.1 (coded by KCNQ1) and calcium-activated KCa3.1 or KCa1.1 channels (coded by KCNN4 and KCNMA1, respectively), in addition to luminal anion channels, including CFTR and/or calcium-activated Cl channels (CaCC) (e.g., TMEM16/ANO1) (reviewed in [46])."
36534232
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"Both types take part in Cl - secretion in rat colon : Ca 2+ -dependent rSK4 channels (Warth et al., 1999) and cyclic AMP activated KCNQ1 and KCNE3 channels (Schroeder et al., 2000)."
12799067
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"KCNQ1 currents were activated by an increase in intracellular cAMP, independent of coexpression with KCNE1 or KCNE3."
11426298
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"There were two types of K+ channels located at the basolateral membrane of rat colon mucosa : Ca2 +-dependent K+ channels and cAMP activated KCNQ1 and KCNE3 channels (Warth et al., 1999; Schroeder et al., 2000; Flores et al., 2007)."
19947937
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"It is known that Cl - secretion induced by quercetin does not require the activation of cyclic AMP activated K + basolateral KCNQ1 and KCNE3 channels (Cermak et al., 2002)."
12799067
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"Taken together, these results indicate that denatonium inhibits the cAMP-activated ion channels CFTR and KCNQ1."
35954259
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"We detected endogenously expressed KCNQ1 and KCNE2 proteins, which appeared to be upregulated by TSH or its major downstream effector, cAMP, in FRTL5 cell membrane fractions (XREF_FIG)."
19767733
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"Specifically, this mutation disrupts the binding between KCNQ1 and Yotiao, reduces PKA phosphorylation of KCNQ1, and eliminates the cAMP induced response of KCNQ1 [XREF_BIBR]."
20689672
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"Increase of intracellular cAMP concentration elevates the driving force for apical Na + uptake by activating basolateral cAMP-sensitive KCNQ1 K + channels ( Mall et al., 2000b )."
15496313
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", cAMP-activated K + channel or KCNQ1/KCNE3 and Ca 2+ -activated K + channel or K Ca 3.1), and basolateral transporters, including Na + –K + ATPases and Na + –K + –Cl − cotransporter 1 (NKCC1) [2,4] ."
26297981
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"Elevations in the levels of cAMP, cyclic guanosine monophosphate (cGMP), and Ca 2+ activate apical Cl - channels (CFTR and CaCC) and basolateral K + channels (KCNQ1 and KNE3, KCNN4)."
22850599
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"Forskolin, a specific cAMP agonist, increased KCNQ1 channel currents in a rapid and sustained manner which were inhibited by chromanol 293B, a specific inhibitor of KCNQ1 channels."
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"The cAMP activated cystic fibrosis transmembrane conductance regulator (CFTR) and KCNQ1 channels in tracheal epithelium play key roles in luminal and basolateral membranes, respectively."
17567648
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"KCNQ1/KCNE2 K+ channels are stimulated by cAMP, and low extracellular pH was found to increase KCNQ1/KCNE2 current (158, 159)."
31670611
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"Because XREF_FIG suggests that co-expression of KCNE2 and KCNQ1 should result in functionally responsive channels to cAMP challenges, we next tested whether an external application of a membrane permeable cAMP (cpt-cAMP) enhances KCNE2 and KCNQ1 currents (note that in all experiments Yotiao was also expressed)."
19077539
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"The gastric KCNQ1 and KCNE channels are activated by cAMP [XREF_BIBR - XREF_BIBR], which thus stimulates gastric acid secretion [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
21113728
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"Mutations at KCNQ1 residue 27 ablated the cAMP induced enhancement of KCNE2 and KCNQ1 currents regardless of substituted amino acid residue (XREF_FIG), suggesting that the cAMP dependent functional regulation is a consequence of PKA mediated phosphorylation at Ser 27 of KCNQ1."
19077539