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USP18 bound to IFNAR2 inhibits Interferon. 2 / 2

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"USP18 directly binds to IFN-alpha and beta receptor 2 (IFNAR2) in human KT-1 cells and, by competing for JAK1 binding, inhibits type I IFN signaling."

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"Indeed, USP18 binds to IFNAR2 to inhibit type I IFN signaling and subsequently disrupting IFNAR2-JAK1 interaction, thus negatively regulating IFN signaling cascades [XREF_BIBR]."

27227879

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Statements

USP18 bound to IFNAR2 inhibits Interferon. 2 / 2

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