IndraLab

Statements

USP18 bound to IFNAR2 inhibits Interferon. 4 / 4
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"USP18 directly binds to IFN-alpha and beta receptor 2 (IFNAR2) in human KT-1 cells and, by competing for JAK1 binding, inhibits type I IFN signaling."
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"It was shown that USP18 directly interacted with IFN-α/β receptor 2 (IFNAR2) in human KT-1 cells, and competed for the binding of JAK1 to suppress type I IFN signaling [113,114] ."
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"Moreover, USP18 is recruited by STAT2 and associates with IFNAR2, thereby displacing JAK1 and suppressing IFN signaling ."
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"Indeed, USP18 binds to IFNAR2 to inhibit type I IFN signaling and subsequently disrupting IFNAR2-JAK1 interaction, thus negatively regulating IFN signaling cascades [XREF_BIBR]."
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