IndraLab

Statements

USP22 activates sorafenib. 3 / 3
| 3
reach
"Why USP22 has a preference for H2BK120ub as its substrate under Sorafenib treatment is worth further research.In summary, our study demonstrated that USP22 promotes the growth of hepatocellular carcinoma and resistance to Sorafenib‐induced ferroptosis by removing ubiquitin moieties from non‐histone protein CDK11B and histone H2B."
40341781
reach
"USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising CDK11B and enhances resistance to Sorafenib by inhibiting ferroptosis through the USP22/H2BK120ub/TFRC axis.So far, more than 40 USPs have been directly or indirectly associated with relevant cancer processes."
40341781
reach
"The USP22 targeting lipopolyplexes caused high tumour inhibition and high sorafenib sensitivity in mice bearing HCC."
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