IndraLab
Statements
reach
"Mice lacking IL-1RI signaling fail to produce a protective type I IFN response after administration of TLR9 ligand (CpG), suggesting that regulation of DUBA expression by IL-1 signaling attenuates TLR9-mediated proinflammatory responses.In virus-induced sepsis, the virus triggers a strong inflammatory response by activating the host’s immune system, where overactivation of the type I interferon pathway and the NF-κB signaling pathway often leads to SIRS and cytokine storm (61, 62)."