IndraLab

Statements

USP4 binds PKM2. 14 / 14
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reach
"This conclusion is supported by the following evidence: First, we confirmed the interaction between USP4 and PKM2."
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reach
"Taken together, our biochemical assay revealed that USP4 was specifically bound to PKM2."
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sparser
"This conclusion is supported by the following evidence: First, we confirmed the interaction between USP4 and PKM2."
37624791
sparser
"The results showed that USP4 is associated with PKM2, and they are co-localized in the cytosol and nucleus."
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sparser
"The available information generally supports the interaction between PKM2 and USP4, although it is not specific to PKM2's ubiquitin state."
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sparser
"We demonstrated the interaction between USP4 and PKM2 by co-expressing these proteins in 293T cells."
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sparser
"Our results showing the interaction using both overexpressed and endogenous proteins across multiple cell lines provide strong evidence for a direct physical interaction between USP4 and PKM2."
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sparser
"USP4 interacts with PKM2 and catalyzes the de-ubiquitination of PKM2."
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sparser
"In this study, we found that USP4 interacts with PKM2 and catalyzes PKM2 de-ubiquitination."
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sparser
"Furthermore, we sought to determine whether USP4 interacts with PKM2 in vivo."
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sparser
"Although we are not able to determine the exact region of PKM2 that interacts with USP4 based on our current results, we postulate that the interacting region of PKM2 with USP4 may localize in the overlapping region of the five deletion mutants."
37624791
sparser
"Taken together, our biochemical assay revealed that USP4 was specifically bound to PKM2."
37624791
sparser
"The above results prove that USP4 interacts with PKM2."
37624791
reach
"To further verify the association between PKM2 and USP4, we performed co-immunoprecipitation experiments."
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