IndraLab

Statements

reach
"USP8 also modulates immune responses by affecting the NF-κB signaling pathway through its interaction with tumor necrosis factor receptor-associated factor 6 (TRAF6)."
38474186
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"Inhibiting USP8 impairs TGF-β/SMAD signal transduction, leading to reduced stability of the β receptor II (βRII) and a decreased quantity of TβRII + circulating extracellular vesicles (crEVs), which in turn diminishes CD8 + T-cell exhaustion and reinstates anti-tumor responses [56]."
39979972
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"USP8 activates the TGF-β/SMAD signaling pathway, which can EMT, tumor cell diffusion, and metastasis."
39979972
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"The inhibition of USP8 downregulated the Notch signalling pathway via NICD destabilization, resulting in the retardation of cellular growth, wound closure, and colony forming ability of breast cancer cell lines."
31527799
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"In this study, through the dual screening of GSVA and GSEA, it was found that in the disease group, the high expression of USP8 activated the TGF‐β signaling pathway."
38376054
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"Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway."
36338727
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"USP8 depletion inhibits Wnt/beta-catenin signaling pathway activity."
37311739