IndraLab

Statements

CYLD inhibits STAT3. 7 / 7
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"CYLD reduced activation of p65, JAK2, STAT3, and p38 MAPK as well as fibrin production in livers of Listeria infected WT mice."
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"In WT mice, IL-6 neutralization only slightly reduced pSTAT3 without affecting fibrin (XREF_FIG) indicating that IL-6 induced pSTAT3 is strongly regulated by CYLD, which limits STAT3 activity and STAT3 dependent fibrin production."
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"CYLD knockdown resulted in an increase of pSTAT3 (XREF_FIG) as well as fibrin (XREF_FIG) in Lm infected WT mice."
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"In extension, we newly identified that IL-6 does not only induce STAT3 phosphorylation in hepatocytes XREF_BIBR, but that CYLD strongly reduced IL-6-dependent accumulation of activated STAT3 in hepatic nuclei."
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"In addition, CYLD diminished IL-6-induced STAT3 activity by reducing nuclear accumulation of phosphorylated STAT3."
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"The observation that siRNA mediated inhibition of CYLD in WT mice increased hepatic p-STAT3 and fibrin levels, diminished hemorrhage and significantly increased survival indicates that inhibition of CYLD might be a therapeutic option in severe listeriosis and potentially other infectious diseases including acute lung injury induced by S. pneumoniae XREF_BIBR."
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"In extension to current knowledge, we uncover that the CYLD dependent suppression of STAT3 activity in hepatocytes resulted in a decreased fibrin production, which identifies CYLD as an important regulator of IL-6-induced STAT3 dependent fibrin production."
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