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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Parthenolide inhibits USP7. 3 / 3

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"Here, we report that sesquiterpene lactone parthenolide (PTL) inhibits USP7 activity, assessed with deubiquitinating enzyme activity assays, including fluorogenic Ub-AMC and Ub-Rho 110, Ub-VME/PA labeling and Di-Ub hydrolysis assays."

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"Although Parthenolide preferentially inhibited USP7, it demonstrated partial inhibitory capacity against six other DUBs (USP8, USP21, USP27X, USP30, USP35, and JOSD2)."

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"Parthenolide inhibits ubiquitin specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth."

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Parthenolide inhibits USP7. 3 / 3

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