IndraLab

Statements

Parthenolide inhibits USP7. 6 / 6
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"Although Parthenolide preferentially inhibited USP7, it demonstrated partial inhibitory capacity against six other DUBs (USP8, USP21, USP27X, USP30, USP35, and JOSD2)."
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"Another interesting finding is that parthenolide inhibits the deubiquitinating activity of USP7, but it inhibits the deISGylation activity of PLpro instead of its deubiquitinating activity ( Supplementary Figure S3)."
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"The cluster also includes parthenolide that inhibits ubiquitin-specific peptidase 7 (USP7) [59] and capsaicin that induces proteasome system dysfunction [60]."
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"Parthenolide inhibits ubiquitin specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth."
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"Here, we report that sesquiterpene lactone parthenolide (PTL) inhibits USP7 activity, assessed with deubiquitinating enzyme activity assays, including fluorogenic Ub-AMC and Ub-Rho 110, Ub-VME/PA labeling and Di-Ub hydrolysis assays."
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"However, parthenolide could inhibit the deubiquitinating activity of USP7 ( Supplementary Figure S3), as reported previously [10]."
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