IndraLab

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USP29 increases the amount of TWIST1. 4 / 4
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"As shown in Figure 3G–J and Figure S3O–R (Supporting Information), the knockdown of USP29 significantly decreased the expression of TWIST1, and increased cancer cellular sensitivity to these chemotherapeutic agents both in vitro and in vivo, which could be largely reversed by the reconstitution of TWIST1 in USP29‐depleted cells."

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"20 However, we found that the knockdown of USP29 significantly decreased the protein level of TWIST1, but only slightly affected the protein level of Snail1 in MDA‐MB‐231 and BT549 cells (Figure S2D, Supporting Information)."

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"As shown in Figure 2A and Figure S2B (Supporting Information), the knockdown of USP29 significantly decreased the protein level of TWIST1."

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"Of note, the depletion of USP29 in both MDA‐MB‐231 and BT549 cells significantly decreased the expression of TWIST1 and Vimentin, and increased the expression of epithelial marker E‐cadherin (Figure 3A; Figure S3C,D, Supporting Information), while the reconstitution of TWIST1 in USP29‐deficient cells could dramatically rescue such a change (Figure 3A)."