IndraLab

Statements

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"Overexpression of CYLD Enhances TNF-alpha-Induced Cell Necrosis of Lung Cancer Cells."
27738385
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"In addition, Patrick et al. found that CYLD’s deubiquitase catalytic activity was necessary for the necrosis of colonic epithelial cells and the occurrence of colitis in FADD mice (135)."
34956195
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"Inhibition of CYLD expression inhibits TNF-alpha-induced Jurkat cell program necrosis, indicating that CYLD is a critical regulator of procedural necrosis."
30034339
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"When Caspase 8 activity was inhibited, L929 cells died by necrosis, which was blocked by knockdown of either CYLD or RIPK3 (XREF_SUPPLEMENTARY)."
22037414
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"22 Therefore, we propose that CYLD protein levels decrease to evade the necrosis elicited by sustained high CYLD levels."
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"Overexpression of CYLD-Flag Induces Cell Necrosis of Lung Cancer Cells."
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"Interestingly, CYLD protein levels decreased in late-phase apoptosis, despite consistently upregulated mRNA levels (XREF_FIG), likely due to CYLD cleavage by caspase-8 to prevent necrosis."
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"These reports proved that CYLD induction of necrosis is not limited to a single cell type but that the CYLD-RIPK1 pathway is probably conserved throughout the body."
25342597
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"They inhibit programmed necrosis by cleavage and inactivation of essential necrosis mediators including RIP1, RIP3 and CYLD [XREF_BIBR - XREF_BIBR]."
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"In addition, knockdown of CYLD, a deubiquitinase of RIP1, blocked TNF-alpha-induced necrosis of HT-22 cells."
25093162
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"Therefore, it is possible that CYLD and A20 inhibitors may prevent tissue necrosis in appropriate clinical indications, such as following stroke and heart attack, for which it is currently difficult to limit tissue damage.Bone disorders."
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"Hence, CYLD was thought to promote necrosis by de-ubiquitination of RIP1 at the TNFR-1 membrane complex."
24098568
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"In support of caspase 8 's role in necrosis, cleavage resistant mutants of RIP1, RIP3 and CYLD promote necrosis without an obligate need to inhibit caspases."
24766891
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"All of the data revealed that overexpression of CYLD promoted cell necrosis in lung cancer cells."
27738385
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"We found that expression of GFP tagged wild type CYLD, but not the deubiquitinase inactive mutant C601S, enhanced TNF induced programmed necrosis in CYLD -/- MEFs (XREF_FIG)."
24098568
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"CYLD Promotes TNF-alpha-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells."
27738385