IndraLab

Statements


TP53 binds RFWD3 and MDM2. 8 / 8
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sparser
"In addition, it has been suggested that RFWD3 mediates the ubiquitination of p53/TP53 by forming a RFWD3-MDM2-p53 complex in the late response to DNA damage ( xref )."

sparser
"The RFWD3 protein is an E3 ubiquitin ligase that positively regulates p53 stability by forming an RFWD3MDM2p53 complex, thereby protecting p53 from degradation by MDM2-mediated polyubiquitination xref ."

reach
"RFWD3 is an E3 ubiquitin ligase that positively regulates p53 stability by forming a RFWD3, MDM2, and p53 complex, thereby protecting p53 from degradation by MDM2 polyubiquitination XREF_BIBR, XREF_BIBR."

sparser
"RFWD3 is an E3 ubiquitin ligase that positively regulates p53 stability by forming a RFWD3-MDM2-p53 complex, thereby protecting p53 from degradation by MDM2 polyubiquitination xref , xref ."

reach
"The RFWD3 protein is an E3 ubiquitin ligase that positively regulates p53 stability by forming an RFWD3, MDM2, and p53 complex, thereby protecting p53 from degradation by MDM2 mediated polyubiquitination XREF_BIBR."

sparser
"We found that an E3 ubiquitin ligase RFWD3 (RNF201/FLJ10520) forms a complex with Mdm2 and p53 to synergistically ubiquitinate p53 and is required to stabilize p53 in the late response to DNA damage."

sparser
"RFWD3 is an E3 ubiquitin ligase that controls p53 stability by forming a RFWD3-MDM2-p53 complex, thereby protecting p53 from degradation by MDM2 polyubiquitination. xref xref The role of p53 in the pathogenesis is on interest in this context as well."

reach
"RFWD3 is an E3 ubiquitin ligase that controls p53 stability by forming a RFWD3, MDM2, and p53 complex, thereby protecting p53 from degradation by MDM2 polyubiquitination."