IndraLab

Statements

USP22 increases the amount of SIRT1. 5 / 5
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"USP22 stabilized and promoted the expression of SIRT1 through its deubiquitination function."
35356205
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"Given that SIRT1 is deubiquitinated by USP22 and stabilized at the protein level (Armour etal., 2013; Lin etal., 2012) and previous studies have reported that SIRT1 could negatively influence the chemosensitivity of HCC cells (Chen etal., 2012), our results supported the notion that USP22 increases SIRT1 protein levels in HCC cells."
28417539
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"USP22 knockdown reduced SIRT1 expression in FLT3-ITD AML cells, whereas USP22 overexpression increased SIRT1 levels by increasing protein stability, indicating that USP22 is an important positive regulator of SIRT1 in FLT3-ITD cells."
25280219
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"USP22 upregulated Sirt1 expression by inhibiting its ubiquitin mediated degradation."
33050642
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"In addition, USP22 knockdown prevented c-MYC-mediated reduction of SIRT1 ubiquitination (XREF_FIG) and increase in SIRT1 expression (XREF_SUPPLEMENTARY)."
25280219