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USP22 increases the amount of SIRT1. 14 / 14
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"USP22 expression was regulated by c-MYC and contributed to c-MYC mediated reduction in SIRT1 polyubiquitination and degradation. USP22 directly interacted with and removing polyubiquitin chains from SIRT1 to increase SIRT1 protein stabilization and expression. These results support a role for USP22 in MYC-mediated increase in SIRT1 protein stabilization, and indicate that FLT3-ITD, c-MYC and USP22 form an oncogenic network that enhances SIRT1 expression and activity in leukemic cells."
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"In addition, SIRT1 is a functional mediator of USP22, and USP22 promotes the expression of SIRT1 by directly combining with SIRT1."
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"In addition, USP22 knockdown prevented c-MYC-mediated reduction of SIRT1 ubiquitination (XREF_FIG) and increase in SIRT1 expression (XREF_SUPPLEMENTARY)."
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"USP22, for instance, can directly regulate and upregulate SIRT1 protein levels, which enhances hepatoma cell resistance to sorafenib [20]."
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"USP22 knockdown reduced SIRT1 expression in FLT3-ITD AML cells, whereas USP22 overexpression increased SIRT1 levels by increasing protein stability, indicating that USP22 is an important positive regulator of SIRT1 in FLT3-ITD cells."
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"Depletion of USP22 exhibited no effect on Sirt1 mRNA level, but significantly inhibited Sirt1 protein expression ( Fig. 3 F and G)."
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"USP22 overexpression can increase the SIRT1 protein level and decrease the p53 acetylation level, promoting SLC7A11 expression."
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"Finally, genetic deletion of usp22 gene in mice leads to early embryonic lethality, and loss of USP22 functions causes decreased Sirt1 protein expression.USP22 is critically required for embryogenesis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given that SIRT1 is deubiquitinated by USP22 and stabilized at the protein level (Armour etal., 2013; Lin etal., 2012) and previous studies have reported that SIRT1 could negatively influence the chemosensitivity of HCC cells (Chen etal., 2012), our results supported the notion that USP22 increases SIRT1 protein levels in HCC cells."
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"Moreover, depletion of USP22 or usage of EX527 reduced the Sirt1 protein level and LC3II/LC3I ratio, and enhanced SQSTM1 protein level compared with CTRP9 treatment ( Fig. 4 C)."
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"USP22, a member of the deubiquitinase family, USP22-mediated deubiquitination can stabilize the expression of SIRT1."
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"USP22 upregulated Sirt1 expression by inhibiting its ubiquitin mediated degradation."
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"Moreover, USP22 directly interacts with sirtuin 1 (SIRT1) and positively regulates SIRT1 protein expression, leading to activation of the SIRT1/AKT/ABCC1 pathway and MDR of hepatocellular carcinoma [68]."
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"USP22 stabilized and promoted the expression of SIRT1 through its deubiquitination function."
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