IndraLab

Statements

NFkappaB inhibits CYLD. 4 / 5
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"If NFkappaB upregulates miR-19, relative to CYLD, this pathway ultimately allows for the sustained activation of NFkappaB in T-ALL through the miR-19 mediated inhibition of CYLD [XREF_BIBR]."
29137387
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"Similar to A20, the UCH-type deubiquitylating enzyme CYLD limits NF-kappaB activation by deubiquitylation."
26732666
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"This is also illustrated by the more than 100-fold increase of CFU in both NF-kappaB inhibited WT and Cyld -/- BMDM as compared to a < 10-fold increase in macrophages with ERK1/2 inhibition."
26834734
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"These findings suggested that, by upregulating the expression of miR-130b and consequently inhibiting CYLD, NF-κB sustained its persistent activation and stimulated the progression of bladder cancer."
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