IndraLab

Statements

OTUB2 increases the amount of YAP1. 5 / 5
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"The regulation of YAP expression by OTUB2 was also validated through an in vivo animal study, and the results were consistent with those of the in vitro experiments (Figure 3N and Figure S4D)."
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"Moreover, we detected strong YAP/TAZ protein levels in the metastatic nodules from the lung and brain of the OTUB2 group ( Figure 2 K), suggesting that OTUB2 can increase the levels of YAP/TAZ."
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"This phenomenon indicated that OTUB2 may promoting YAP1 and TAZ protein expression during the development of ESCC, and the role of OTUB2 in promoting the development of ESCC may mainly occur via YAP1 and TAZ."
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"Additionally, overexpression of OTUB2 upregulated YAP expression in a dose-dependent manner but did not affect the expression levels of upstream components of the Hippo pathway, such as LATS1, in either VSMCs or HEK293T cells (Figure 3H and Figure S4C)."
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"OTUB2 silencing decreased the YAP protein level, whereas MG132, but not leupeptin, abrogated this decrease (Figure 5E-F)."
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