IndraLab

Statements



reach
"Administration of C16 from days 2 to 28 post-MI reduced ACE2 activity and was associated with a significant increase in infarct size and reduction in LV contractile function."

eidos
"121 MI increased ACE2 mRNA expression in humans , mice , and rats , 122 , 123 whereas loss of ACE2 or inhibition of ACE2 by C16 , resulted in worsening of MI-induced cardiac dysfunction , increased infarct size , MMP activation , cardiac extracellular matrix disruption , and inflammation ( Table ) ."