IndraLab

Statements

USP16 activates Wnt. 5 / 5
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"Discussion Our data show that Bmi1 and Usp16 , important chromatin regulators in stem cells , modulate Wnt signaling in primary mammary epithelial and fibroblast cells ."
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"Here we report that Usp16, a negative regulator of Bmi1 and PRC1 function, modulates the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential."
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"Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood ."
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"Usp16 copy number normalization restores normal Wnt activation in Ts65Dn mice models."
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"Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation."
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