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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

UBE2E1 activates OTUB1. 2 / 2

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"A comparison of the effect of several different E2 enzymes on OTUB1 DUB activity showed that the UBE2D enzymes and UBE2E1 robustly stimulate OTUB1, although UBE2N only weakly enhanced cleavage of K48 diubiquitin under the conditions tested 37."

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"UBE2E1 protein levels could also be restored in OTUB1 CRISPR knockout cell lines by expressing either FLAG-OTUB1 or untagged OTUB1 (Fig. 2D)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...