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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 inhibits Cell Survival. 2 / 5

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"ATX3 deficiency results in pronounced reduction of Chk1 abundance, compromised DNA damage response, G2/M checkpoint defect and decreased cell survival after replication stress, which can all be rescued by ectopic expression of ATX3."

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"Aggregation of expanded ataxin-3 in PC6-3 ataxin-3 (Q108) cells decreased cell survival only in the presence of high 3-NP concentrations, compared to HEK EGFP-ataxin-3 (Q84) cells or MJD cerebellar granule cells, which may account for a lower expression of the transgene in these cells."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...