IndraLab

Statements

reach
"ATX3 deficiency results in pronounced reduction of Chk1 abundance, compromised DNA damage response, G2/M checkpoint defect and decreased cell survival after replication stress, which can all be rescued by ectopic expression of ATX3."
28180282
reach
"Aggregation of expanded ataxin-3 in PC6-3 ataxin-3 (Q108) cells decreased cell survival only in the presence of high 3-NP concentrations, compared to HEK EGFP-ataxin-3 (Q84) cells or MJD cerebellar granule cells, which may account for a lower expression of the transgene in these cells."
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