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TNF binds TNFRSF11A. 30 / 30
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"RANKL is a member of the tumor necrosis factor (TNF) receptor family that binds RANK to activate the TRAF6-dependent signals that induce osteoclast differentiation and activity ( Dougall et al., 1999 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RANKL is a member of the TNF family that binds to RANK on osteoclast precursors and promotes the production and differentiation of osteoclasts."
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"Thus, TNF-α interacts with RANK to induce osteoclast differentiation, dramatically reducing the expression of osteogenic markers."
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"It binds RANK ligand [RANK-L/osteoprotegerin ligand (OPGL)/TNF-related activation-induced cytokine (TRANCE)], a TNF superfamily member that acts as a trimer."
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"The RANK‐TNF receptor‐associated factor complex activates downstream signal pathways, including the nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NFκB) and mitogen‐activated protein kinase pathways, which lead to the induction and activation of transcription factors such as Fos proto‐oncogene (cFos) and nuclear factor of activated T‐cells, cytoplasmic 1 (NFATc1; Boyce, xref ), resulting in enhanced expression of osteoclast‐specific genes (Kim et al., xref ; Moreaux et al., xref )."
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"RANKL is a cytokine belonging to the Tumor Necrosis Factor (TNF) family, which binds RANK in osteoclast precursors, promoting its differentiation to mature osteoclasts."
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"After NF-κB stimulation, several TNF-receptor (TNFR-) factors are associated with the cytoplasmic domain-associated RANK."
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"The activated PTH/PTH receptor stimulates the secretion of receptor activator of nuclear factor kappa-Β ligand (RANKL), a member of the tumor necrosis factor alpha (TNFα) family that binds to RANK on osteoclast precursors to induce osteoclastic differentiation ( xref ; xref ; xref ; xref )."
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"Using this approach, we examined the role of six RANK putative tumor necrosis factor receptor associated factor binding motifs (PTM) (PTM1, ILLMT-REE (286-293); PTM2, PSQPS (349-353); PTM3, PFQEP (369-373); PTM4, VYVSQTSQE (537-545); PTM5, PVQEET (559-564); and PTM6, PVQEQG (604-609)) in osteoclast formation and function."
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"OPG competes with RANK (receptor activator of nuclear factor κB [NF-κB]) for binding of RANK ligand (RANKL, OPG1) that is also a TNF family member."
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"Further, they may suggest generalization of MMP production through NF-κB activation.RANKL, a TNF family cytokine, binds to its receptor RANK leading to the activation of various signaling pathways in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"One of the major factors of osteoclast differentiation is RANKL (receptor activator of nuclear factor-kB ligand), a cytokine from the TNF superfamily, that interacts with cells through its receptor RANK."
36154881
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"RANKL is a cytokine of the TNF family, which binds to its receptor RANK as initially documented in osteoclast precursors and dendritic cells [ xref ]."
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"Therefore, our results indicate that TRAIL can both promote and suppress osteoclast differentiation, depending on the presence of RANKL or other TNF superfamily molecules, suggesting that TRAIL may pl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, after binding of RANKL , TNF receptor-related factors can bind to the cytoplasmic part of TNFRSF11A and activate intracellular signaling pathways."
33816072
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"Osteoclast differentiation is triggered by RANKL, a membrane-anchored member of TNFα family expressed in bone by stromal/osteoblastic cells, which binds to its receptor RANK on the surface of osteocla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RANKL is a cytokine belonging to the Tumor Necrosis Factor (TNF) family, which binds RANK in osteoclast precursors, promoting its differentiation to mature osteoclasts."
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"RANKL, a TNF superfamily cytokine, binds the receptor RANK expressed on osteoclast precursors and osteoclasts and induces the expression of factors required for osteolysis by osteoclasts (i.e., cathepsin K, TRAP) [21]."
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"Such regulation is tightly controlled by transcription factors and also by miRNA.For the third target, we identified that TNF-α activates the inflammatory pathways by binding to TNF receptors, such as TNFRSF11A, also called RANK, in the context of CF."
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"XREF_BIBR, XREF_BIBR In the downstream cascade, transduction factor TNF receptor associated factors (TRAFs), especially TRAF6, can bind to RANK to activate NF-kappaB and the JNK/AP -1 pathway."
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"STRING protein–protein interaction and functional enrichment analysis highlighted that Lcn2 directly interacts with the tumor necrosis factor ( Tnf ), which, in turn, interacts with the RANK gene and the Nfatc 1 gene, thus influencing the expression of downstream genes Cst 1, Cts k, Mit f, and TRAP ."
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"Although these results suggest that TNF-α induces osteoclast differentiation through TNFR1/TNFR2, there were still two possibilities that TNF-α directly binds to RANK or TNF-α increases endogenous production of some factor(s) that can interact with RANK."
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"RANKL (receptor activator nuclear factor-κB ligand) is a member of TNFα that binds to RANK (receptor activator of nuclear factor-κB), a membrane receptor."
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"RANKL is a tumor necrosis factor that stimulates osteoclasts by binding to RANK."
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"The RANK-TNF complex activates downstream pathways leading to the upregulation of key transcription factors involved in osteoclast differentiation, including nuclear factor kappa‐light‐chain‐enhancer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The RANK-TNF complex activates downstream pathways leading to the upregulation of key transcription factors involved in osteoclast differentiation, including nuclear factor kappa‐light‐chain‐enhancer [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"During osteoclastogenesis, ROS are produced by RANKL through RANK-tumor necrosis factor (TNF)-receptor-associated factor 6 (TRAF6)-Rac1 signaling [ xref , xref ]."
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"RANK, XREF_BIBR a new member of the membrane bound TNF receptor family (TNFRSF11A), has been cloned as a receptor for RANKL in immune systems, and it is the signaling receptor for RANKL in osteoclastogenesis as well."
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"The binding of TNF-α to TNFR 1 and RANKL to RANK recruits the necessary adaptor molecules and initiates the downstream signalling cascade."
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"Osteoprotegerin (OPG) is a soluble tumor necrosis factor receptor molecule that is secreted and binds to the RANK activating site of OPGL, acting as a "dummy" or "decoy" receptor and preventing OPGL from binding to and activating the osteoclast RANK receptor [89] (Fig. 2)."
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