IndraLab

Statements

USP18 inhibits IFN receptor. 5 / 5
| 5
reach
"Whereas ISG15 conjugation has been widely recognized to act antivirally 13, unconjugated ISG15 serves a proviral role by promoting USP18 mediated suppression of type I IFN receptor (IFNAR) signaling XREF_BIBR, XREF_BIBR, XREF_BIBR; this latter function of ISG15 is responsible for over-amplified ISG induction and fortified viral resistance in humans with inherited ISG15 deficiency."
33140045
reach
"USP18 is upregulated by type I IFNs and interacts with STAT2 to negatively regulate type I IFN receptor signaling, while ISG15 binds and stabilizes USP18."
39028870
reach
"On the other hand, the deubiquitinating enzyme USP18 can also directly inhibit type I IFN receptor signaling, thereby suppressing the immune response (Arimoto et al., 2017)."
34901029
reach
"A majority of these genes are responsible for the regulation and control of early innate inflammation, such as USP18, which disrupts the JAK-STAT pathway downstream of the IFN receptor (43), and TIFAB, which inhibits the activation of the NF-κB pathway (44)."
35012339
reach
"USP18 regulates antiviral responses by removing ISG15 conjugates and can directly inhibit type I IFN receptor signaling by binding the subunit 2 of the receptor via STAT-2 XREF_BIBR, XREF_BIBR."
30890331