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USP29 inhibits Mice. 4 / 4
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"In our previous study, we revealed that USP29 promoted tumor cell aerobic glycolysis and glutamine anaplerosis by deubiquitinating and stabilizing the oncogenic MYC family and HIF1α, and systemic knockout of USP29 significantly suppressed tumor progression and prolonged the survival of tumor-bearing mice."
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"In addition, SIRT1 activity was increased in USP29-suppressed mice but further decreased in USP29-overexpressed mice (Figure 4(e))."
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"Therefore, we tried to clarify whether BMAL1 is required for SIRT1-mediated cerebroprotection in USP29-suppressed mice."
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"Moreover, in H/R-stimulated hepatocytes, phosphorylated TAK1 was significantly elevated in the absence of USP29 and significantly decreased in the USP29 overexpressing mice (Figure 6F)."
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