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"Remarkably, silencing USP22 reduced the tumor volume of BEL/FU cells treated with 5-FU (BEL/FU control shRNA cells treated with 5-FU vs BEL/FU USP22 shRNA treated with 5-FU, 945 +/-545mm 3 vs 372 +/-228mm 3, P < 0.05)."