IndraLab

Statements

USP47 activates CDC25A. 5 / 5
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"However, USP47 deficiency inhibits SCF (β‐TrCP) degradation of Cdc25A, promotes apoptosis, and enhances the cytotoxicity of anticancer drugs.F‐box dysfunction will affect the survival of tumor cells."
39812503
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"Notably, genetic or siRNA mediated depletion of USP47 induced accumulation of Cdc25A, decreased cell survival and augmented the cytotoxic effects of anticancer drugs."
19966869
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"Depletion of USP47 induced accumulation of Cdc25A and decreased cell survival [XREF_BIBR]."
28122328
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"Moreover, USP47 depletion induced upregulation of Cdc25A to similar levels as the silencing of betaTrcp (XREF_SUPPLEMENTARY)."
19966869
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"Moreover, we found that in response to hydroxyurea, Cdc25A was degraded in USP47 depleted cells to similar levels as in control cells (XREF_FIG), implying a transcriptional regulation of Cdc25A induced by USP47 depletion."
19966869