IndraLab

Statements

Peptide inhibits NFKB1. 5 / 5
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"The 22 amino acid NBD peptide, corresponding to the NEMO-binding domain (NBD; MW: 199.5 Da) of the IKKα subunit of the canonical nuclear factor-κB (NF-κB)-activating IkB complex, inhibits canonical NFkB activation without inhibiting noncanonical (or basal) NF-kB activity [112,113]."
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"SN50 is a cell permeable peptide that consists of nuclear localization sequence of the NF-κB subunits p50 and blocks the import of p50-containing dimers into the nucleus."
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"Using SN50, a forty-one-residue synthetic peptide that contains a hydrophobic membrane-translocating region and prevents the nuclear localization sequence of NF-κB p50, we were able to repress the promoter activity of CD47 and decrease its mRNA transcription in the presence of LPS (Figure 7C)."
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"This anti-inflammatory effect is exerted on both immune cells and intestinal epithelial cells via specifically stimulating a new type of human IL-10 producing Treg cells [104] and bacterial-derived peptide inhibition of NFkB activation [105] respectively.MSCs also trigger the upregulation of several anti-regulatory modulators such as Foxp3+ regulatory T cells, Th17 and Th1 cells in CD and Th2 cells in UC [106, 107]."
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"Similarly, we developed an ELP fusion to a peptide inhibitor of the p50 subunit of nuclear factor-kappa B (NF-kB) that can specifically block the activity and downstream inflammatory signaling of NF-kB in vitro and in vivo ."
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