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Peptide inhibits NFKB1. 3 / 3
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"This anti-inflammatory effect is exerted on both immune cells and intestinal epithelial cells via specifically stimulating a new type of human IL-10 producing Treg cells [104] and bacterial-derived peptide inhibition of NFkB activation [105] respectively.MSCs also trigger the upregulation of several anti-regulatory modulators such as Foxp3+ regulatory T cells, Th17 and Th1 cells in CD and Th2 cells in UC [106, 107]."
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"] Leukoc Biol 2007; 82:801-810; LoiarroM, Sette C, Gallo G et al. Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-KB."
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"Using SN50, a forty-one-residue synthetic peptide that contains a hydrophobic membrane-translocating region and prevents the nuclear localization sequence of NF-κB p50, we were able to repress the promoter activity of CD47 and decrease its mRNA transcription in the presence of LPS (Figure 7C)."
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