IndraLab

Statements

OTUB1 activates ossification. 4 / 4
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"Homozygous loss of Otub1 results in impaired bone formation and reduced bone mass owing to defects in osteogenesis."
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"OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2."
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"Research indicates that E3 ubiquitin ligases are involved in regulating osteoblast differentiation and bone formation, such as OTUB1 promoting bone formation by stabilizing FGFR2, and Parkin inhibiting RANKL-induced osteoclastogenesis."
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"In this study, we unveil the positive role of OTUB1 in osteoblast-mediated bone formation by maintaining FGFR2 stability and the osteogenesis effects of OTUB1 provide an optical therapeutic strategy to alleviate osteoporosis."
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