IndraLab

Statements

UCHL5 activates proteolysis. 4 / 4
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"It has been shown that UCHL5 controls proteasome function and inhibition of UCHL5 promotes protein degradation in autophagy XREF_BIBR."
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"The RNAi of UCHL5 or USP14 alone does not affect cell growth and proteasome composition but accelerates cellular protein degradation; however, RNAi of both UCHL5 and USP14 can inhibit cellular protein degradation."
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"Double knockdown of Ubp6/USP14 and Uch37/UCHL5 results in inhibition of cell growth, decreased protein degradation, and accumulation of polyubiquitinated proteins, a phenotype similar to that observed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RNAi of both Uch37 and Usp14 also had no effect on proteasome structure or proteolytic capacity, but inhibited cellular protein degradation."
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