IndraLab

Statements

USP18 activates NFkappaB. 3 / 4
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"These results suggested that the suppression of NF-kappaB signaling by USP18 is mainly dependent on the inhibition of K63 linked polyubiquitination of NEMO on lysine residues at positions 325 and 326."
26240016
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"Knockdown of USP18 enhances NF-kappaB activation as well as the inflammatory response."
26240016
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"Therefore it is tempting to suggest that early induction of NF-kappaB (24hpi) mediated by USP18 during PRRSV infection, via increasing and decreasing nuclear translocation of p65 and p50, respectively, is detrimental for viral growth."
22796444