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"Some systematic literature reviews show that KRAS and BRAF V600E mutations are negatively associated with OS and RFS in patients who undergo complete liver resection for CRLM. xref , xref , xref , xref In particular, BRAF V600E mutations that present in 8%‐10% of patients are consistently associated with poor prognosis and result in possible patient ineligibility for resection of CRLM. xref , xref "