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USP8 deubiquitinates SQSTM1. 11 / 11
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"USP8 directly deubiquitinates SQSTM1 and p62 and blocks autophagy [XREF_BIBR]."
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"USP8 directly deubiquitinates SQSTM1 and p62 and blocks autophagy [XREF_BIBR]."
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"For example, the deubiquitinating enzymes ubiquitin specific peptidase 8 (USP8) can directly bind to and deubiquitinate SQSTM1 ( Peng et al., 2020 )."
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"USP8 overexpression leads to deubiquitination of p62 protein, suppressing its autophagic activity (Peng et al. 2020)."
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"USP8 induces deubiquitination of BECN1 and p62 protein related to autophagy induction."
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"Having shown that USP8 induces the deubiquitination of TRAF6, TAB2, and TAK1, and resulted in the attenuation of NF-κB activation induced by TLR4 stimulation, we further investigated whether USP8 induces the deubiquitination of BECN1 and p62."
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"It has been reported that USP8 deubiquitinates p62 (Peng et al., 2020), but USP8 depletion had little effect on the total ubiquitination levels of p62 under our experimental conditions (Fig. S5, C and D)."
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"Myc-p62 was ubiquitinated in the absence of Flag-USP8 (Fig. 2E, lane 3), whereas marked deubiquitination could be seen in the presence of Flag-USP8 in a dose-dependent manner (Fig. 2E, lane 4–6 vs. lane 3), indicating that USP8 induces the deubiquitination of p62."
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"By deubiquitinating SQSTM1 at K420, USP8 negatively regulates the autophagy [28] ."
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"Additionally, USP8 interacted with p62 and BECN1, which are key regulatory proteins for the induction of autophagy through the TRAF6-dependent ubiquitination (Fig. 8, right) [23,24,48,49], and induced the deubiquitination of p62 and BECN1."
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"Simultaneously, USP8 interacts with BENC1 and p62, and induces the de-ubiquitination of BECN1 and p62, thereby inhibits the induction of autophagy (Fig. 8, right)."
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