IndraLab

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USP8 deubiquitinates SQSTM1. 4 / 4
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"USP8 directly deubiquitinates SQSTM1 and p62 and blocks autophagy [XREF_BIBR]."

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"USP8 directly deubiquitinates SQSTM1 and p62 and blocks autophagy [XREF_BIBR]."

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"USP8 overexpression leads to deubiquitination of p62 protein, suppressing its autophagic activity (Peng et al. 2020)."

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"USP8 induces the deubiquitination of TRAF6, TAB2, TAK1, p62, and BECN1, which are pivotal roles for NF-κB activation and autophagy induction."