IndraLab

Statements

USP2 binds PER1. 14 / 14
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"These findings show that USP2 binds PER1 directly and indicate that the interaction of USP2 with the other clock proteins is indirect and possibly occurring within a complex that contains components known to participate in the main negative feedback loop of the circadian clock, including PER1."
23213472
sparser
"Earlier studies from our lab showed that USP2 directly interacts with ubiquitinated PER1 (Yang et al.  xref ) and facilitates its localization to the nucleus (Yang et al.  xref )."
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"USP2 can be coimmunoprecipitated with several clock proteins but directly interacts specifically with PER1 and deubiquitinates it."
23213472
sparser
"In our hands, whereas it forms a complex with several clock proteins, USP2 directly binds only to PER1 ( xref )."
25147498
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"These findings show that USP2 binds PER1 directly and indicate that the interaction of USP2 with the other clock proteins is indirect and possibly occurring within a complex that contains components known to participate in the main negative feedback loop of the circadian clock, including PER1."
23213472
reach
"For example, USP2 binds directly to PER1 in order to regulate PER1 intracellular localization [XREF_BIBR]."
26473939
sparser
"Previous studies have shown that USP2 directly interacts with PER1 and affects its localization (Yang et al.  xref )."
39967311
sparser
"However, in vitro assays indicated that USP2 could only interact directly with PER1, suggesting that USP2 interacts with the other clock proteins by virtue of their being in a complex with PER1 ( xref )."
23213472
sparser
"The USP2 protein binds and deubiquitinates PER1, regulating its nuclear localization [ xref , xref ]."
40002179
sparser
"For example, USP2 binds directly to PER1 in order to regulate PER1 intracellular localization [ xref ]."
26473939
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"USP2 interacts directly with PER1."
23213472
reach
"However, in vitro assays indicated that USP2 could only interact directly with PER1, suggesting that USP2 interacts with the other clock proteins by virtue of their being in a complex with PER1 (XREF_FIG)."
23213472
sparser
"USP2 interacts directly with PER1."
23213472
reach
"In our hands, whereas it forms a complex with several clock proteins, USP2 directly binds only to PER1."
25147498