IndraLab

Statements

USP28 leads to the ubiquitination of FBXW7. 3 / 3
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"In contrast, complete knockout of Usp28 triggers autocatalytic ubiquitination and degradation of Fbw7, sparing Fbw7 substrates."
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"USP28 deletion is associated with 53.2%-9.7% of breast cancer cases, which reveals that USP28 gene deletion-mediated disruption of FBXW7 auto-ubiquitination might correlate with breast cancer development in certain way, but this remains to be further investigated [51]."
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"Complete knockdown of USP28 in mice triggers the auto-ubiquitination of FBXW7 and leads to substrate accumulation, while maintaining the single allele deletion of USP28 partially restores FBXW7 expression, and substrate protein levels are reduced in all mouse tissues [50]."
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