IndraLab

Statements

CRSP binds SCN8A. 5 / 5
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"This intriguing finding raises the possibility that the canonical CRSP and MED complex may also be dramatically altered and possibly disposable during terminal differentiation."
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"Interestingly, MED1 expression was only detected in fibroblasts while none of the C2C12 derived skeletal muscle cell types expressed detectable levels of this largest subunit of the CRSP and MED complex (XREF_FIG)."
18851836
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"It has been well established that in addition to TFIID, the multi and subunit complex CRSP and MED can function to mediate activator dependent transcription."
18851836
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"To directly test the requirement for CRSP and MED complex in our reconstituted transcription reactions, we have incubated our Myogenin template with TAF3 and TRF3, MyoD and E47 and CRSP and MED complex."
18851836
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"Although these observations suggest that the CRSP and MED complex may also be altered or possibly discarded in differentiated myotubes, more work is required to dissect the fate of CRSP and MED."
18851836